Quentin Beck was an expert in designing special effects devices and stage illusions, as well as a master hypnotist and magician, and an amateur chemist. He also possessed a wealth of knowledge in hand-to-hand combat techniques that he learned as a stuntman. Unfortunately, all these things did little to help his career in the film industry. One day, a colleague joked that the easiest way to become famous was to take out a costumed hero. It was here that Mysterio was born.
Mysterio was created by Stan Lee and Steve Ditko and first appeared in The Amazing Spider-Man #13 (1964).